Abstract: Separation of strontium and calcium is very important in the production of high-purity strontium chemicals,and in the industrial application of single strontium ore,associated strontium ore or brine strontium ore with high content of calcium.The present of research and industrial application situation of separation methods for the two elements by precipitation,solvent extraction and ion exchange method etc.have been reviewed and remarked on the basis of some fundamental properties of strontium and calcium.Lastly,the advantages and disadvantages of these separation methods were compared and the prospect of the use of strontium in strontium brine was also expected.