Core-shell structure TiO₂@SiO₂ was prepared by parallel flow method using rutile TiO₂ as the core and sodium silicate as the coating agent.The influence of seven single factors including pH,temperature,stirring rate,coating time,initial concentration of TiO₂,coating amount and aging time on acid solubility of products were explored by single factor experiment.The preparation process was optimized by response surface experiment.The obtained product was characterized by TEM,XPS,SEM,XRD,FT-IR and UV-Vis.The results showed that when mixing rate was 300 r/min,the coating time was 60 min and the initial mass concentration of TiO₂ was 200 g/L,the order of influence of the four factors was as follows: coating dose> coating temperature>pH>aging time.The optimal conditions were as follows: the content of coating agent was 4.41%,the temperature was 83.65 ℃,the pH was 9.59 and the aging time was 25.62 h.Under the conditions,the acid solubility of the product reached 3.43%.The shell layer was amorphous SiO₂ with a thickness of about 5 nm and was chemically bonded on the surface of TiO₂ nucleus by Ti-O-Si.Core-shell structure TiO₂@SiO₂ has the higher UV shielding capability.