Abstract: Pb/ZSM-5 was the most widely applied catalyst in synthesizing the pyridine in industry.The aldehyde ammonia condensation reaction on lead/alumina (Pb/Al<SUB>2</SUB>O<SUB>3</SUB>) catalyst was studied.Effects of reaction parameters,such as different Al<SUB>2</SUB>O<SUB>3 </SUB>carrier,b loading amount;calcination temperature of catalyst on catalytic performances were investigated and the Pb/Al<SUB>2</SUB>O<SUB>3</SUB> catalyst was characterized by XRD.The results showed that the optimum conditions were：Al<SUB>2</SUB>O<SUB>3</SUB>&nbsp; carrier′s specific surface was 170~185 m<SUP>2</SUP>/g;pore volume was 1.6~2.0 cm<SUP>3</SUP>/g;and average pore size was 34 nm;loading amount of Pb was 2.5%～4.0% (mass fraction);and calcination temperature of catalyst was 500～550 ℃.Under these conditions the performances of the prepared catalyst were the best and the yield of alkylpyridine could reach 90%.<BR>