To improve acid resistance of Ti-based lithium ionic sieve β-H₂TiO₃ in the process of engineering application，the high acid-resistant β-H₂TiO₃ was synthesized in this study using different proportions of rutile and anatase TiO₂ as mixed Ti sources.And the effect of the ratio of mixed crystal TiO₂ on the adsorption capacity，ion selectivity and acid resistance of lithium ion sieve was studied.The optimal ratio of mixed crystal titanium source was also optimized and cyclic stability of the lithium ion sieve was tested.The resuils showed that when the mass content of anatase TiO₂ in titanium source for synthesis of β-H₂TiO₃ were 0，20%，40%，60%，80% and 100%，increasing the anatase TiO₂ content in the titanium source led to an increase in the adsorption capacity of β-H₂TiO₃，and there was no significant negative effect on ion selectivity.The acid resistance test results showed that when the content of anatase TiO₂ in the titanium source was 40%，the mass residual rate of β-H₂TiO₃ after acid soaking could be significantly increased，which was 65%，and the attenuation degree of adsorption properties of the remaining was minimal.XRD and SEM characterization results of the residue after acid soaking showed the β-H₂TiO₃ synthesized from single crystal TiO₂ as titanium source could form anatase type TiO₂ new phase after soaking in 1 mol/L hydrochloric acid.When the anatase TiO₂ content in the titanium source was 40%，no new phase formed after the β-H₂TiO₃ soaked with acid.The adsorption capacity of the β-H₂TiO₃ remained stable at about 17 mg/g after 30 cycles of testing，which was better than that of β-H₂TiO₃ synthesized by single crystal TiO₂ as titanium source.In summary，using mixed crystal TiO₂ as titanium source to synthesize lithium ion sieve could improve the acid resistance and cycle life.It provided direction and guidance for preparation of high stability Ti-based lithium ion sieve in engineering.