Single-factor experiment cannot comprehensively and reliably study the influence of various factors on the pre-paration of high-quality lithium carbonate during the reaction crystallization process.Taguchi′s design is conducive to the comprehensive study of various factors to prepare high-quality lithium carbonate.The experiment cycle is shorter and the experiment cost is lower.Using the refined brine of Dongtai Jinel Salt Lake as the raw material,Taguchi experiment was designed,and the focused beam reflection measuring instrument FBRM G400 was used to study effect of the reaction temperature,stirring rate,brine feed rate,Na₂CO₃ concentration and other factors on the reaction crystallization process in real-time on-line study of the lithium carbonate particle size and purity.Taguchi experiments showed that the stirring rate had the greatest influence on the particle size of lithium carbonate,and the purity of lithium carbonate was most sensitive to the reaction temperature.The results of the study showed that when the reaction temperature was 85 ℃,the stirring rate was 200 r/min,the brine feed rate was 2 mL/min,and the mass concentration of Na₂CO₃ was 201.6 g/L,the quality of obtained lithium carbonate was the best with particle size of 3.71 μm and purity of 99.62%.