Inorganic Chemicals Industry ›› 2020, Vol. 52 ›› Issue (5): 18-21.doi: 10.11962/1006-4990.2019-0385

• Research & Development • Previous Articles     Next Articles

Preparation of SERS substrate Ag@Au and its detection of ofloxacin

Cheng Hao1,2,Xu Yajuan1,2,Li Lijun1,2,Huang Wenyi1,2,Lu Hao1,2,Feng jun2,3()   

  1. 1.Guangxi Key Laboratory of Green Processing of Sugar Resources,College of Biological and Chemical Engineering,Guangxi University of Science and Technology,Liuzhou 545006,China;
    2.Province and Ministry Co-sponsored Collaborative Innovation Center of Sugarcane and Sugar Industry;
    3.School of Medicine,Guangxi University of Science and Technology
  • Received:2019-11-19 Online:2020-05-10 Published:2020-05-21
  • Contact: Feng jun E-mail:hxpfengjun@163.com

Abstract:

A bimetallic Ag@Au nanoparticle with uniform morphology,uniform particle size and good dispersibility was syn-thesized by seed-mediated growth method and used as a surface-enhanced Raman scattering(SERS) substrate for ofloxacin (OFLX) testing.Firstly,the main Raman peak of ofloxacin was assigned under the optimal experimental conditions,and the 1 416 cm -1 Raman characteristic peak was selected.Secondly,the characteristic peak intensity of 1 416 cm -1 was linearly fit-ted with the concentration of ofloxacin.The curve equation was Y=291.48X+3 156.8,r=0.989,and the detection limit reached 10 -10 mol/L.The method is simple in operation,high in sensitivity and good in reproducibility,and can provide a basis for SERS detection of ofloxacin antibiotic drugs.

Key words: SERS, Ag@AuNPs, ofloxacin

CLC Number: