采用多级离子交换法对加氢精制催化剂载体进行脱钠处理，考察了铵盐种类、浸泡时间、交换温度和铵盐浓度对脱钠效果的影响。以浸泡时间、交换温度和铵盐浓度3个主要影响因素做Box-Behnken实验设计，钠含量为响应函数，建立相应数学模型。实验结果表明，脱钠效果较优的铵盐为乙酸铵。最佳工艺条件：浸泡时间为60 min、交换温度为60 ℃、铵盐质量分数为5.5%。Box-Behnken实验设计法用于加氢精制催化剂载体脱钠工艺优化是可行的，数学模型的预测值与实验观察值相符。

The method of multi stage ionexchange was used to remove sodium from hydrogenation refining agent carrier.The effect of factors，such as ammonium salts，soaking time，exchange temperature and ammonium salt concentration，were investi gated.The Box-Behnken experiment design was carried out with three main influencing factors: soaking time，exchange tempera ture and ammonium salt concentration.The sodium content was the response function and the corresponding mathematical model was established. Results showed that the ammonium salt with better removing sodium effect was ammonium acetate.The best experimental conditions were as follows：the soaking time was 60 min，the exchange temperature was 60 ℃and the mass frac tion of ammonium salt was 5.5%.Removing sodium from the hydrogenation refining agent carrier by Box-Behnken experiment design is feasible，and the prediction values of the mathematical model are in line with the experimental observation.