Abstract: Cupric sulfate produced with oxidized copper ore contained many inorganic ions which have seriously influenced on the quality of products.In order to improve product quality,a method for the determination of aluminum and manganese ions content in cupric sulfate was confirmed through massive experiments.Aluminum ions determines with spectrophotometric method,this method is quick and easy operation,recovery rate in the sample can be 99.2%~101.12%,relative standard deviation(n=6) is 1.98%.Manganese ions determines with flame atomic absorption,this method is quick,accurate,and more precise,the recovery rate in the sample can be 99.72%~101.40%,relative standard deviation(n=6) is 1.34%.